Proper laser preparation centers on two things above all else: strict sun avoidance in the weeks leading up to treatment, since tanned or sunburned skin significantly increases the risk of complications, and pausing certain active skincare ingredients that can increase sensitivity, typically for three to seven days beforehand depending on the specific product and treatment.

Why sun exposure matters so much?

Most laser treatments work in part by targeting pigment in the skin, whether that's pigment in a hair follicle, a blood vessel, or the skin's own melanin. A recent tan increases overall melanin in the skin, which can cause the laser to inadvertently affect more of the surrounding skin than intended, increasing the risk of burns, blistering, or unwanted pigment changes. Most providers recommend avoiding direct sun exposure, tanning beds, and self-tanner for at least two weeks before treatment, with daily sunscreen use throughout that window.

Which skincare ingredients should you pause beforehand?

  • Retinoids (retinol, retinal, tretinoin): typically paused three to seven days before treatment, since they can increase skin sensitivity and the risk of irritation.
  • Exfoliating acids (AHAs, BHAs): also generally paused in the days leading up to treatment for the same reason.
  • Certain prescription acne medications: some, like isotretinoin, require a much longer pause, sometimes six months, due to how they affect skin healing — always confirm timing with your provider if you're on one of these medications.

Your specific pre-treatment instructions will vary depending on which laser and treatment area you're having done, so always follow your provider's specific guidance over general rules of thumb.

What other preparation steps are worth knowing?

For laser hair removal specifically, shaving the treatment area the day before (rather than waxing or plucking, which removes the hair follicle the laser needs to target) is typically recommended. For treatments involving topical numbing cream, arriving with clean skin, free of makeup and lotion in the treatment area, helps the numbing cream absorb properly. If you have a history of cold sores and are having a treatment near the mouth, mentioning this beforehand allows your provider to consider a preventive antiviral medication, since certain laser treatments can trigger an outbreak.

What medical history is worth flagging?

Certain medications, including some antibiotics and other photosensitizing drugs, can increase the risk of an adverse reaction to laser treatment, so a complete, updated medication list at your consultation is genuinely important, not just a formality. The same goes for any history of keloid scarring, active skin infections in the treatment area, or recent other cosmetic procedures nearby.

What should you do the night before and day of treatment?

Arrive with clean, product-free skin in the treatment area, avoid caffeine and alcohol if you tend to be sensitive to discomfort, and plan to wear sunscreen immediately after treatment and consistently in the days that follow, since newly treated skin is especially vulnerable to sun-related complications during healing.

How do you get personalized guidance?

Because pre-treatment instructions vary by laser type and treatment area, your provider will give you specific, written guidance ahead of your appointment — following it closely is one of the simplest ways to protect both your results and your safety.

1. A published review of pre-treatment skincare protocols for ablative laser resurfacing recommends nightly 0.1% tretinoin cream for three months beforehand, discontinued 24 hours prior to treatment, as a regimen shown to speed healing and reduce the risk of complications.
Pre-treatment instructions vary by device, treatment area, and individual medical history. Always follow your provider's specific guidance. This article is educational and does not replace individualized medical advice.